Study of possible radioprotective properties of deanol aceglumate under the action of ionizing radiation on human cells

One of the effective methods to mitigate late side effects radiotherapy is use radioprotectors that reduce harmful ionizing radiation on living cells. Nowadays there are no ideal and multifunctional radioprotectors. In this connection, research priority search for new able protect healthy cells from therapy. A promising compound can be used as a radioprotector deanol aceglumate. Deanol aceglumate known low-toxic nootropic drug. addition, evidence its hepatoprotective antioxidant activity. The aim study investigate potential properties human fibroblasts (hTERT) gamma-radiation C-12 ions select optimal time cell incubation with prior irradiation. effect was evaluated by criteria doubling clonogenic It shown at concentration 1000 mcM has radioprotective exposed gamma radiation. irradiation 24 hours in order achieve highest effect. does not normal when beyond Bragg Peak. been found depend significantly quality way radiation-induced diverse during therapy cancer patients.